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Tottenham’s Dele Alli starts a three-game European ban against Borussia Dortmund in the Champions League.
The midfielder was sent off for a dangerous tackle as Gent knocked them out of the Europa League in February.
Dortmund could be without up to nine first-team players through injury.
“Dele is a big miss. He’s a fantastic player who has been great for us,” said striker Harry Kane, who scored his first two Spurs goals of the season against Everton on Saturday.
“But we’ve got a fantastic squad, so whoever comes in will be ready.”
While White Hart Lane is rebuilt, Spurs are playing all their home games this season at Wembley, where they have won once in 11 appearances over the past nine years.
They played all their home European games there last season, failing to qualify from their Champions League group as they dropped into the Europa League, where they were then eliminated by Gent in the first knockout round.
“With Wembley, we need to adapt our game,” said boss Mauricio Pochettino. “We need to feel that Wembley can be home. In the last few games we’ve played at Wembley, we’ve played well and deserved more.”
Spurs are in one of the toughest Champions League groups, with Real Madrid playing Apoel Nicosia in Wednesday’s other match.
“In theory, it’s Real Madrid first and then Tottenham, Dortmund and Apoel to compete for second,” said Pochettino. “But football is not theories. Our ambition is to try to win every game.”
Erik Lamela (hip), Danny Rose (knee) and Victor Wanyama (knee) all remain sidelined.
Dortmund are unbeaten this season, with a German Cup win over Rielasingen-Arlen and two wins and a draw in the Bundesliga.
They have plenty of absentees – with Neven Subotic falling ill on Tuesday. Captain Marcel Schmelzer (ankle ligaments) and fellow defender Marc Bartra (groin) have not travelled to London.
Also likely to miss out are Julian Weigl (ankle), Andre Schurrle (thigh), Sebastian Rode (knock) and Erik Durm (hip). Raphael Guerreiro is recovering from a foot operation, and Marco Reus from knee surgery.
“Our long-term injuries are well-known and we have some short-term ones as well,” Dortmund manager Peter Bosz said.
“Subotic is sick. Maybe he will come tomorrow but he is not with the group today.”
- Tottenham and Dortmund’s only previous encounter was in the last 16 of the 2015-16 Europa League. The German side won 5-1 on aggregate (3-0 in Germany, 2-1 in England), courtesy of three goals by Pierre-Emerick Aubameyang and two by Marco Reus.
- Tottenham are in the Champions League group stages for the third time, after 2010-11 (quarter-finals) and 2016-17 (group stages). It is the first time they have reached this stage in consecutive seasons.
- Spurs have won only two of their past nine Champions League games (D2 L5). They have also won only one of their three games at Wembley in the competition (L2).
- They are winless in their opening game of a Champions League group stage (D1 L1).
- Despite playing only three games in his Champions League career, Harry Kane has scored two goals.
- This is Maurico Pochettino’s second Champions League campaign as manager. He failed to make it out of the group stages with Tottenham last season.
- This is Borussia Dortmund’s 12th appearance in the Champions League – only Bayern Munich can boast more among German clubs (21).
- Dortmund have reached the knockout stages in their past four Champions League campaigns. This includes 2012-13 when they were beaten finalists against Bayern Munich.
- Borussia Dortmund – winners in 1997 – are one of three German clubs to have lifted the European Cup, along with Bayern Munich (five) and Hamburg (one).
- Only three of Borussia Dortmund’s past 32 Champions League games have ended in a draw (W17 D12).
- Marco Reus has scored 12 goals and delivered four assists in his past 16 Champions League games.
- This is Peter Bosz’s first Champions League campaign as manager.